postoperative recovery and perioperative organ protection
Conditions
Interventions
Intervention group:Intravenous methylprednisolone 120mg at anesthetic induction
Dexmedetomidine infusion at a rate of 0.4ug/kg/h after induction until the end of surgery
Volatile anesthetic to maintain anesthesia.
Control group:Use the same technique to give the same amount or rate of normal saline at the same time point mentioned above, and use total intravenous anesthesia (propofol) throughout the surgery to
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years; 2. Undergoing heart valve surgery with cardiopulmonary bypass; 5. Written inform consent.
Exclusion criteria
Exclusion criteria: 1. Heart rates < 50 beats per min, sick-sinus syndromes, second-degree or above atrioventricular block; a myocardial infarction within 7 days, left ventricular ejection fraction <30%, use of clonidine to treat hypertension, hemodynamically significant arrhythmia; 2. Severe cerebral, hepatic, renal disease, a history of systematic infection in the preceding 30 days, a family history of malignant hyperthermia, insulin-treated diabetes; 3. A history of allergy to any of the study drugs, or exposure to any of the study drugs within 30 days; 4. Pregnant or breast-feeding; 5. Participation in another experimental protocol at the time of intervention selection; 6. Refused to cooperate or be inappropriate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Days at home up to 30 days after surgery (DAH30); | — |
Secondary
| Measure | Time frame |
|---|---|
| Major adverse cardiovascular cerebral event (MACCE);Postoperative acute kidney injury;5-level EQ-5D score;Postoperative mortality;Length of ICU stay;Duration of mechanical ventilation after surgery;Length of postoperative hospital stay;Hospitalization cost;Peak blood glucose;New atrial fibrillation; | — |
Countries
China
Contacts
Public ContactHai Yu
Outcome results
None listed