Airway disease
Conditions
Interventions
Group A:S(+)-ketamine 0.25mg/kg
Group B:S(+)-ketamine 0.15mg/kg
Group Control:normal saline
Sponsors
The Hefei Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing flexible bronchoscopy under general anesthesia; 2. Aged between 18 to 75 years old male and female; 3. volunteered to sign the informed consent of the trial.
Exclusion criteria
Exclusion criteria: 1.Patients with history of known allergy to dexmedetomidine or midazolam; 2.Patients with impairment of language, mental, comprehension and inability to communicate properly; 3.Patients with history of neuropsychiatric disorders, drug dependence and alcohol abuse; 4.Patients with serious cardiovascular and cerebrovascular diseases, or major organ dysfunction preoperatively; 5.Patients who are participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Richmond agitation-sedation scale;VAS score;Hamilton Depression Scale;Orientation recovery time;i-gel airway extubation time;IL-6;TNF-a;superoxide dismutase;glutathion peroxidase;catalase; | — |
Secondary
| Measure | Time frame |
|---|---|
| Drug dose;MMSE;adverse reaction; | — |
Countries
China
Contacts
Public ContactWensheng He
The Hefei Affiliated Hospital of Anhui Medical University
Outcome results
None listed