Postoperative cognitive dysfunction
Conditions
Interventions
Cognitive frailty group:No
Cognitive normal group:No
Sponsors
Shanghai Tongji Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Without anesthesia drug allergy history; 2. Always inadvertently cerebrovascular disease or related operation history; 3. Without neurological or mental illness; 4. Without taking antipsychotic drugs for a long time or history of antidepressant drugs. 5. No alcohol dependence or substance abuse: no hearing and speech disorders; 6. Simple mental state scale score higher than the corresponding cultural level of the lowest score: illiteracy (not education) or greater 17 points, primary school education (education duration of less than or equal to 6 years) 20 points or higher, secondary school or above education (education duration of more than 6 years) or greater 23 points.
Exclusion criteria
Exclusion criteria: 1. Ruled out the use immune inhibitors or immunomodulatory therapy; 2. Known to influence cognitive function of chemotherapy drugs; 3. In cognitive tests during severe head trauma or undergoing chemotherapy; 4. Don't participate in neuropsychological testing or during perioperative MRI inspectors; 5. Patients transferred to intensive care unit (ICU) after operation 6. Such as postoperative cerebral embolism, cerebral hemorrhage, pulmonary infection patients with serious complications
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive assessment scales; | — |
Secondary
| Measure | Time frame |
|---|---|
| Head MRI;Biochemical factors associatedactors associated; | — |
Countries
China
Contacts
Public ContactJianhui Liu
Shanghai Tongji Hospital
Outcome results
None listed