Ovarian hyperstimulation syndrome
Conditions
Interventions
group 1: GnRHantagonist
group 2:GnRHagonist
group 3:letrozole
Sponsors
Women and Children's Hospital Affiliated to Xiamen University
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1) Women aged 20-40 in the first assisted pregnancy cycle; 2) GnRH antagonist or long IVF / ICSI; 3) GnRHa or hCG trigger; 4) E2 >= 4680pg / ml and / or oocyte number >= 20 on hCG day; 5) All embryos were frozen.
Exclusion criteria
Exclusion criteria: 1) Severe heart, liver and kidney diseases; 2) Using coasting to prevent OHSS during ovulation induction; 3) Taking drugs that affect vascular permeability during art; Exclusion criteria: 1) Continued participation in clinical trials will cause unnecessary harm to the subjects; 2) The compliance of the subjects was poor, and they could not use the medicine on time and in quantity; 3) Use other drugs or foods that affect tolerance judgment or pharmacokinetic results; 4) At the same time, other treatments were used to evaluate the effect; 5) The subjects who did not meet the inclusion criteria were found after participating in the trial; 6) The subjects who met the exclusion criteria were found after participating in the trial; 7) The subjects who fell out; 8) In addition to the above situations, other subjects deviated from or violated the protocol during the trial and affected the drug equivalence evaluation or safety evaluation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of early onset moderate to severe OHSS;Estradiol;progesterone;Hematocrit;C-reactive protein; | — |
Countries
China
Contacts
Public ContactLin Jin
Women and Children's Hospital Affiliated to Xiamen University
Outcome results
None listed