Degenerative lumbar disease
Conditions
Interventions
A:Upper intervertebral space filling with rhBMP-2 self-curing calcium phosphate artificial bone (granular) inferior intervertebral space filling artificial bone
B:Superior intervertebral space filling Allograft bone inferior intervertebral space filling rhBMP-2 self-curing calcium phosphate artificial bone (granular)
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
40 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. The patients were diagnosed as L3-5 degenerative instability or degenerative spondylolisthesis within Meyerding grade II, and all patient with or without lumbar spinal stenosis; 2. Patients were suffering from Clinical symptoms correspond to radiological outcomes (such as chronic low back pain with or without lower limb radiative pain). 3. All patients had been underwent conservative treatment for > 6 months without effect; 4. Patients were at least 18 years old (skeletally mature); 5. Patients who agree with take part in this clinical study.
Exclusion criteria
Exclusion criteria: 1. The patients were diagnosed as servent lumbar scoliosis, isthmic spondylolisthesis, multiple lumbar degenerative stenosis(over 3 leverls), lumbar fractures, severe osteoporosis (T score less than -2.5), and degenerative spondylolisthesis classified as higher than Meyerding grade II; 2. Non-agreement between the radiological diagnosis and the clinical symptoms;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| fusion rate;fusion percentage; | — |
Countries
China
Contacts
Public ContactJiancheng Zeng
West China Hospital of Sichuan University
Outcome results
None listed