The clinical effects of small-dose esketamine on preventing the pain of injection with propofol.

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100043324

Enrollment

Unknown

Registered

2021-02-10

Start date

2021-02-09

Completion date

Unknown

Last updated

2021-06-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The pain of propofol injection

Interventions

S0.05:0.05 mg/kg esketamine

S0.075:0.075 mg/kg?????

S0.15:0.15 mg/kg esketamine

S0.3:0.3 mg/kg esketamine

NS:normal saline

L:lidocaine 40mg

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. All patients with ASA grade I-II were enrolled; 2. Subjects aged 18-65 years old; 3. Patients scheduled for otology surgery under general anesthesia; 4. Those subjects who knew and agreed to the study and signed the consent form.

Exclusion criteria

Exclusion criteria: 1. Subjects allergic to experimental drugs; 2. Subjects with severe risk of elevated blood pressure or intracranial pressure; 3. Subjects with hypertension (blood pressure > 170 / 100 at rest); 4. Subjects with hyperthyroidism; 5. Subjects with severe organ dysfunction; 6. Patients with obvious ischemic heart disease; 7. Subjects with sinus tachycardia; 8. Subjects who abuse alcohol or analgesic, sedative or antidepressant drugs.

Design outcomes

Primary

Measure	Time frame
Ambesh score;	—

Secondary

Measure	Time frame
heart rate;blood pressure;dosage of vasoactive drug;VAS score;adverse events;	—

Countries

China

Contacts

Public ContactJie Jia

Ophthalmology and Otolaryngology Hospital Affiliated to Fudan University

jiajie@eentanesthesia.com+86 13641839213

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026