Myocardial injury
Conditions
Interventions
Deep neuromuscular block group:Deep neuromuscular block was maintained intraoperatively, TOF=0, PTC=1-2
Moderate neuromuscular block group:Moderate neuromuscular block was maintained intraoperatively, TOF=1-2
Sponsors
Xuanwu Hospital of Capital Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 79 Years
Inclusion criteria
Inclusion criteria: 1. Patients with informed consent; 2. The subjects, aged 60-79 years, who planned to undergo elective laparoscopic radical resection of colorectal cancer; 3. Subjects with operation time more than 2 hours; 4. ASA II - III subjects; 5. Subjects with BMI of 18.5-30 kg / m2.
Exclusion criteria
Exclusion criteria: 1. Patients with severe cardiovascular disease had abnormal myocardial markers before operation; 2. Patients with severe respiratory diseases, such as COPD, pulmonary infection, bronchial asthma, etc; 3. Patients with severe liver dysfunction; 4. In patients with severe renal dysfunction, creatinine clearance rate was less than 30ml / min; 5. Patients with known or suspected neuromuscular diseases; 6. Subjects allergic to the drugs involved in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| serum TnI level; | — |
Secondary
| Measure | Time frame |
|---|---|
| serum Myo level;serum CK-MB level;serum NT-proBNP level;postoperative pain score;PONV degree;dosage of general anesthetics;Incidence of cardiovascular system complications;Incidence of respiratory system complications;Incidence of AKI; | — |
Countries
China
Contacts
Public ContactLei Zhao
Xuanwu Hospital of Capital Medical University
Outcome results
None listed