Climacteric syndrome
Conditions
Interventions
Group 1:oryzanol injection for 5 days
Group 2:oryzanol injection for 10 days
Sponsors
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
Female
Age
40 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. The subjects who can sign the informed consent form voluntarily agree to participate in the study; 2. Women aged 40-60 years; 3. Subjects with menstrual disorder for more than 3 months or menopause for more than 1 year; 4. Subjects with modified K-index score >= 16; 5. Subjects without contraindications of oryzanol injection; 6. Subjects who can receive oryzanol injection for at least 5 days.
Exclusion criteria
Exclusion criteria: 1. Subjects allergic to oryzanol injection or any drug components; 2. Subjects who had been treated with hormone drugs in the past three months; 3. Pregnant and lactating women; 4. Patients with history of endometriectomy, ovariectomy and hysterectomy; 5. Patients with sleep disorders caused by neuropsychiatric diseases and other physical diseases, such as depression, anxiety disorder and sleep apnea syndrome, etc.; 6. Cardio hepatic renal insufficiency includes the following criteria: (1) Serum AST / ALT and bilirubin were more than twice the upper limit of normal; (2) Creatinine was more than twice the normal upper limit; 7. Patients with active autoimmune diseases; 8. Suffering from any disease that the researcher believes makes the patient unfit for the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Kupperman Score Scale;MENQOL score, PSQI sleep score; | — |
Countries
China
Contacts
Public ContactChen Rong
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
Outcome results
None listed