Non-small cell lung cancer
Conditions
Interventions
case series:Nil
Sponsors
Cancer Hospital of Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Subjects aged 18-75 at the time of signing the informed consent; 2. Subjects with negative EGFR / ALK gene and unresectable NSCLC of limited or extensive stage confirmed by histopathology or cytology; 3. Subjects who have not received immune checkpoint therapy drugs (PD-1 / PD-L1 / CTLA4, etc.); 4. According to recistv1.1 standard, those subjects with at least one measurable tumor focus; 5. Subjects with ECoG PS of 0 or 1; 6. The patients or their families are willing to cooperate with the complete drug treatment tracking requirements.
Exclusion criteria
Exclusion criteria: 1. Subjects with metastatic cancer found in brain and other nervous systems; 2. Patients with acute or chronic hepatitis B or hepatitis C infection; 3. Subjects with active, known or suspected autoimmune diseases (type I diabetes, hypothyroidism with hormone replacement therapy only, except for skin diseases without systemic treatment); 4. Patients with previous malignant tumors (except bladder cancer, gastric cancer, colon cancer, endometrial cancer, breast cancer and other cancers in situ), unless they have been completely cured at least 2 years before participating in the study, and no additional treatment is required during the study; 5. Subjects who have received any chemotherapy, biological products for cancer treatment or experimental therapy within 28 days before the first administration; 6. Patients who refuse or are unable to complete the informed consent related communication of the study, or patients who withdraw from the study for some reason during the study; 7. For other exclusions, please consult the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 5hmC;5mC; | — |
Countries
China
Contacts
Public ContactWang Jie
National Cancer Center, Chinese Academy of Medical Sciences and Peking Union Medical College
Outcome results
None listed