Protective effect of remote ischemic preconditioning combined with sevoflurane posttreatment on myocardial injury during laparoscopic radical resection of colorectal cancer

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100043313

Enrollment

Unknown

Registered

2021-02-10

Start date

2021-04-01

Completion date

Unknown

Last updated

2021-06-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Laparoscopic radical resection of colorectal cancer

Interventions

total intravenous anesthesia:Propofol anesthesia

Sevoflurane posttreatment:Sevoflurane anesthesia

Propofol combined with sevoflurane anesthesia:Propofol combined with sevoflurane anesthesia

RIPC and propofol anesthesia:Remote ischemic preconditioning and propofol anesthesia

RIPC and sevoflurane posttreatment:Remote ischemic preconditioning and sevoflurane anesthesia

RIPC and propofol combined with sevoflurane anesthesia:Remote ischemic preconditioning and propofol combined with sevoflurane anesthesia

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Subjects with ASA grade II to III; 2. Subjects aged 50-75 years old weighing 55-75kg; 3. Subjects of NYHA grade II to III.

Exclusion criteria

Exclusion criteria: 1. Subjects with ECG showing heart block; 2. Subjects with preoperative left ventricular ejection fraction (LVEF) < 40%; 3. Subjects with incomplete limbs had myocardial infarction in the past three months; 4. Patients with history of nervous system, immune system and mental diseases; 5. Subjects who used cardiotonics or needed mechanical assistance for heart failure before operation, those who had important organ diseases or underwent surgical treatment; 6. Subjects who used drugs that can improve myocardial blood supply and dilate cardiovascular system before operation; 7. Patients participating in other clinical trials.

Design outcomes

Primary

Measure	Time frame
blood pressure;heart rate;SPO2%;Blood gas analysis;Central venous pressure;H-FABP;cTnI;TNF-a;IL-8;	—

Secondary

Measure	Time frame
BIS value;Anesthetics dosage;The anesthesia time;The operation time;Age, gender, BMI;Adverse reactions;Hospital costs;Hospital costs;	—

Countries

China

Contacts

Public ContactChun Tian

Yongchuan Hospital Affiliated to Chongqing Medical University

272605765@qq.com+86 15723059158

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 10, 2026