Effects of oral appliance intervention on vascular endothelial function, inflammatory response and hypercoagulability in carotid atherosclerosis patients with OSAHS

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100043309

Enrollment

Unknown

Registered

2021-02-09

Start date

2021-02-01

Completion date

Unknown

Last updated

2021-06-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obstructive sleep apnea syndrome, carotid atherosclerosis

Interventions

Intervention group:Oral appliance

control group:Nil

Eligibility

Sex/Gender

All

Age

33 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Patients with carotid atherosclerosis; 2. Subjects without severe disability.

Exclusion criteria

Exclusion criteria: 1. Smoking subjects; 2. Subjects with severe heart, liver, kidney and other organ dysfunction; 3. Patients with stroke; 4. Subjects who had received OSAHS intervention treatment; 5. Patients who can not insist on wearing oral appliances; 6. Patients with poor oral periodontal health, temporomandibular joint disorder, etc. who can not tolerate wearing oral appliances; 7. Subjects with airway obstruction caused by abnormal anatomical structure of nasopharynx or pathological factors.

Design outcomes

Primary

Measure	Time frame
Routine blood;C-reactive protein;Interleukin-6;Breathless index (BHI);Fibrinogen;D - dimer;Blood fat;	—

Countries

China

Contacts

Public ContactYing Zhao

Capital Medical University Xuanwu Hospital

zhying19@aliyun.com+86 13910165600

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026