Hematological malignancies
Conditions
Interventions
Sponsors
Shanghai Zhaxin Integrated Traditional Chinese and Western Medicine Hospital
Eligibility
Sex/Gender
All
Age
14 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients with positive target markers confirmed by flow cytometry had primary drug resistance, relapse during chemotherapy, and relapse after drug withdrawal or hematopoietic stem cell transplantation; 2. Subjects aged 14-70 years old, including boundary value; Chinese nationality 3. Patients over 18 years old with self-knowledge ability voluntarily sign the informed consent, and children under 18 years old voluntarily sign the informed consent by their legal representative (Guardian); 4. Subjects with ECoG score of 0-3; 5. Women of childbearing age who had negative pregnancy test before the trial and agreed to take effective contraceptive measures during the trial until the last follow-up.
Exclusion criteria
Exclusion criteria: 1. Patients with severe acute organ dysfunction, such as liver dysfunction (alt, AST are more than 10 times higher than the normal range), renal dysfunction (BUN, SCR are more than 2 times higher than the normal baseline value), severe arrhythmia or heart failure, dyspnea or respiratory failure; 2. Patients with coagulation dysfunction and bleeding of important organs; 3. Patients with intracranial hypertension or cerebral disturbance of consciousness, or other central nervous system diseases; 4. Subjects with bloodstream infection or other uncontrollable infection; 5. Subjects with grade 2 aGVHD or moderate cGVHD; 6. Subjects with active hepatitis B or C virus infection, syphilis, HIV, cytomegalovirus and Epstein Barr virus infection; 7. Patients with other types of malignant tumors; 8. Pregnant or lactating women; 9. Any situation that the researcher believes may increase the risk of the subject or interfere with the test results.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Safety evaluation index;Pharmacokinetic evaluation index;Curative effect evaluation index; | — |
Countries
China
Contacts
Public ContactChun Wang
Shanghai Zhaxin integrated traditional Chinese and Western Medicine Hospital
Outcome results
None listed