periodontal intrabony defect
Conditions
Interventions
Control group:MIST alone
Experimental group:MIST combined with bovine porous bone mineral and GTR
Sponsors
Peking University School of Stomatology
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed of advanced periodontitis, in general good health, presenting with at least one isolated intrabony defect, after completion of initial therapy and between 18 and 65 years old are considered eligible for this study; 2. Patients are able to sign informed consent and with good compliance; 3. Defect locate in the proximal area of single-rooted teeth or in the mesial aspect of first molars; 1) probing pocket depth (PPD) and clinical attenchemnt level (CAL) >=5mm at baseline; 2) intrabony defect >= 3mm after surgical debridement; 3) with adequate keratinized gingiva to cover bone defects and materials; 4) the distance between root apex and defect base >= 3 mm on X-rays; 5) extension to the oral side on CBCT; 4. Good oral hygiene: full-mouth plaque score <=20% (FMPS<=20%); 5. Low levels of residual infection: full mouth bleeding score <=25% (FMBS<=25%).
Exclusion criteria
Exclusion criteria: 1. Poor oral hygiene; 2. Pregnancy or lactation; 3. Oral cancer and HIV infection; 4. History of regenerative surgical treatment of study teeth; 5. Teeth with more than grade II mobility; 6. Teeth with III furcation involvement; 7. Untreated acute infection, apical lesions, imperfect root canal treatment, root fracture, severe root deformities, cementum beads, indelible enamel projects, untreated caries at the cemento-enamel junction or root surface, and restoration reaching subgingival or / and incongruous restoration edges of the study teeth; 8. Smoking more than 10 cigarettes per day; 9. Participation in other clinical study within the past 30 days; 10. Patients with oral leukoplakia or mucosal proliferative erythema; 11. Allergy to the regenerative materials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical attachment level (CAL);bone morphology;radiographic linear bone gain; | — |
Secondary
| Measure | Time frame |
|---|---|
| early healing index (EHI);post-operative discomfort and pain;pocket probing depth (PPD);bone probing level (BPL);gingival recession (GR);percentage of bone fill;volume of intrabony defect accessed by CBCT; | — |
Countries
China
Contacts
Public ContactOuyang Xiangying
Peking University School of Stomatology
Outcome results
None listed