Knee osteoarthritis
Conditions
Interventions
Experimental group:PRP was injected three times
control group:????PRP
Sponsors
Henan Provicial People's Hospital
Eligibility
Sex/Gender
All
Age
30 Years to 75 Years
Inclusion criteria
Inclusion criteria: Knee osteoarthritis 1) Chronic joint pain or swelling (> 4 months); 2) According to the diagnostic criteria of knee osteoarthritis recommended by American College of Rheumatology, X-ray or MRI examination showed degenerative changes, that is, the X-ray evaluation results were in accordance with Kellgren Lawrence grade I to grade III or MRI results without degenerative changes of osteoarthritis X-ray.
Exclusion criteria
Exclusion criteria: 1) Aged over 80 years; 2) K-L grade > III; 3) Patients combined with rheumatoid arthritis, severe osteoporosis, tumor, gout and obvious joint deformity; Diabetes, blood disease, serious cardiovascular disease, infection; have taken anticoagulants, immunosuppressants in the past, or took NSAIDs within 5 days; 4) Patients with poor compliance, fail to treat as required; Those who have used intra-articular injection or non steroidal analgesics within 2 weeks; 5) Patients with recent history of knee arthroscopy or knee surgery; 6) Hemoglobin < 11 g / L, platelet < 1.5 x 10 ^ 9 / L, severe coagulopathy; 7) Body mass index (BMI) is too high or too low; 8) Pregnant women and lactating women; 9) Serious adverse events occurred; 10) The patients withdrew from the study by themselves; 11) During the follow-up period, the patients were lost to follow-up for various reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MRI;Joint function evaluation, WOMAC, IKDC, HSS, KSS;VAS;Incidence of complications; | — |
Countries
China
Contacts
Public ContactWeisheng Zhuang
Henan Provincial People's Hospital
Outcome results
None listed