The impact of perioperative systolic blood pressure management on the prognosis of elderly patients with high-risk major surgery: a prospective randomized controlled trial

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100043258

Enrollment

Unknown

Registered

2021-02-09

Start date

2021-02-03

Completion date

Unknown

Last updated

2021-06-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perioperative management of elderly patients

Interventions

control group:SBP was maintained above 90 mmHg or from baseline to 40% below the baseline during operation

treatment group:Maintain intraoperative systolic blood pressure within ±10% of the baseline value

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Older than 65 years old; 2.ASA is larger than grade II; 3.Non-cardiac and non-neurosurgical procedures with operation time >= 2 hours.

Exclusion criteria

Exclusion criteria: 1.Severe preoperative hypertension (uncontrolled); 2.Creatinine clearance rate <30 ml/min or preoperative dialysis; 3.Acute heart failure; 4.Preoperative sepsis; 5.Preoperative hemodynamic failure (shock); 6.Intraoperative use of spinal anesthesia.

Design outcomes

Primary

Measure	Time frame
Incidence of postoperative deliriumand MMSE scores on the 1st, 3rd, and 7th days after surgery, and the cognitive function telephone questionnaire score (TICS-m score) at 1 month after surgery;	—

Countries

China

Contacts

Public ContactLi Rui

The Second Hospital of Anhui Medical University

lrayd@sina.com+86 13855114159

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026