Relapsed and refractory multiple myeloma
Conditions
Interventions
Sponsors
Beijing Boren Hospital
Eligibility
Sex/Gender
Male
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. RRMM patients with CART treatment targets (CS-1 or CD319/SLAMF7) still have residual lesions after two-line treatment and have negative BCMA expression or progress after BCMA-CART treatment; 2. The patient must have an assessable disease certificate, including minimal residual disease; 3. Aged 18-75 years, including boundary value, self-knowledge, able to sign informed consent; 4. The expected survival period is more than 3 months; 5. ECOG score 0-2 points; 6. Women of childbearing age who had a negative blood pregnancy test before the start of the test and agreed to take effective contraceptive measures during the test period until the last follow-up.
Exclusion criteria
Exclusion criteria: 1. Intracranial hypertension or unconsciousness; 2. Symptomatic heart failure or severe arrhythmia; 3. Respiratory failure; 4. With other types of malignant tumors; 5. Diffuse intravascular coagulation; 6. Serum creatinine and/or urea nitrogen >= 1.5 times the normal value; 7. Sepsis or other infections that are difficult to control; 8. Uncontrollable diabetes; 9. Severe mental disorder; 10. There are obvious intracranial lesions in head MRI examination; 11. Cerebrospinal fluid examination of myeloma cells>20/ul; 12. The proportion of blood tumor cells > 30%; 13. ECOG score >= 2 points; 14. Organ transplant recipients; 15. Pregnant and lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Safety index;Effectiveness index; | — |
Countries
China
Contacts
Public ContactKai Hu
Beijing Boren Hospital
Outcome results
None listed