Psoriasis
Conditions
Interventions
Normal control group:no
Sponsors
General Hospital of Ningxia Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed with psoriasis with Psoriasis area and severity index (PASI) score >= 12, course of disease >= 6 months were considered as the candidates. 2. The healthy controls and psoriasis patients have not been treated by any drug in at least four weeks. 3. All healthy controls have no any sign of metabolic syndrome. 4. All the inclusions have not taken any pickled food including yogurt and salted vegetables for at least one week. 5. All the participants have not used any skin moistures or sprays for at least one week.
Exclusion criteria
Exclusion criteria: Patients who meet any of the followings are excluded. 1. Allergy to oxymatrine. 2. Theres adverse side effect like presence of severe liver and/or kidney damage, mental illness, hematopoietic dysfunction, or other severe organ dysfunctions. 3. Patients who received any treatment with immunosuppressants, high-dose glucocorticoids or retinoid in the past 8 weeks. 4. Patients who are in pregnancy or lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Psoriasis area and severity index;Whole blood viscosity;Inflammation related factors in psoriasis;Oxidation antagonism;Cell proliferation related factors in psoriasis;Apoptosis related factors in psoriasis;Psoriasis pathway related factors;Changes of skin metabolism;Changes of serum metabolism;Serum lipid composition;Lipid composition of skin;Intestinal microbiome;Skin microbiome;Relationship among microorganisms, proteins and metabolites;Genomics;Metabonomics;Proteomics;Lipomic;Pathological changes of skin;Immunohistochemical staining of skin tissue; | — |
Secondary
| Measure | Time frame |
|---|---|
| Body Surface Area (BSA);dermatology life quality index (DLQI);Physician Global Assessment (PGA);electrocardiogram;Routine biochemical examinations;Routine urine tests;Routine blood tests;Abdominal color Doppler ultrasound; | — |
Countries
China
Contacts
Public ContactHuijuanShi
General Hospital of Ningxia Medical University
Outcome results
None listed