Effects of individualized PEEP titration guided by driving pressure on pulmonary function and inflammatory factors in patients undergoing radical prostatectomy assisted by robot

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100043236

Enrollment

Unknown

Registered

2021-02-09

Start date

2021-02-18

Completion date

Unknown

Last updated

2021-06-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

prostatic carcinoma

Interventions

control group:Small tidal volume (Vt 6ml/kg) fixed PEEP (5 cmH2O)

experimental group:Small tidal volume (Vt 6ml/kg)?P guided individualized titration PEEP

Eligibility

Sex/Gender

All

Age

65 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.Selection of patients undergoing radical prostatectomy by robotic radical prostatectomy; 2.Aged 65-80 years; 3.BMI 19-28 kg/?; 4.ASA classification: grade II ~ III.

Exclusion criteria

Exclusion criteria: 1. Refused to participate in the experiment and did not sign informed consent; 2. patients with severe respiratory complications or severe pulmonary insufficiency, including difficult airways, asthma, thoracic diseases, pulmonary restrictive and obstructive diseases, thoracic and spinal deformities; 3. with severe cardiovascular complications, including congenital heart disease, severe arrhythmia, coronary heart disease, myocardial infarction, heart failure, cardiomyopathy, etc; 4. suffering from cerebrovascular disease, craniocerebral tumor, craniocerebral trauma and other diseases, including pituitary adenoma, cerebral hemorrhage, cerebral infarction and so on; 5. suffering from mental disorders such as nervous disorders, depression, long-term insomnia, or long-term use of psychotropic drugs; 6. have undergone thoracic or neurosurgery or have undergone surgery in the last six months; 7. the ventilation strategy used during surgery can not maintain oxygenation in patients (SpO2 < 94% or 70 mmHg); 8. ventilation strategies used during surgery result in severe hypotension and difficult maintenance of fluid rehydration and vasoactive drugs (arterial systolic blood pressure <90 mmHg or mean arterial pressure <50 mmHg); 9. peak airway pressure was higher than 40 cmH2O; during operation; 10. Severe complications during surgery due to mechanical ventilation strategies (e.g. pneumothorax).

Design outcomes

Primary

Measure	Time frame
Respiratory indicators;inflammatory factor;Blood gas analysis indicators;	—

Secondary

Measure	Time frame
vital sign;	—

Countries

China

Contacts

Public ContactTian shouyuan

Department of Anesthesiology, Shanxi Medical University

chinatsyjj@126.com+86 13803401773

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026