Brain Injury
Conditions
Interventions
Gold Standard:(1) Detailed medical history inquiry
(2) Detailed medical examination
(3) Conventional CT/MRI imaging examination
(4) Special imaging examination.
GFAP 
(Glial 
Protein)
PGP9.5 
Gene 
9.5)
 
S100-ß
Sponsors
Xiang'an Hospital of Xiamen University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: This study will enroll 70 to 80 patients with mild to moderate traumatic brain injury, 70 to 80 patients with early ischemic and hemorrhagic stroke, and 40 to 50 patients without brain injury. The subjects include outpatients, emergency patients and inpatients in Xiang'an Hospital of Xiamen University. The subjects randomly include men and women of all ages. Experimental blood samples will be collected during the routine clinical blood sample collection process.
Exclusion criteria
Exclusion criteria: (1) Patients with severe brain injury; (2) Patients requiring craniotomy; (3) Patients with mild brain injury but no CT imaging examination; (4) Patients with severe coronary heart disease, heart failure or renal failure; (5) Patients with malignant tumor; (6) Patients taking various drugs that may cause increased BBB permeability. (7) Patient with other uncontrolled active infection; (8) The investigator believes that the subject is not suitable for this clinical study due to different reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| GFAP (Glial Fibrillary Acidic Protein);PGP9.5 (Protein Gene Product 9.5); | — |
Secondary
| Measure | Time frame |
|---|---|
| S100-ß;NSE (Neuron Specific Enolase); | — |
Countries
China
Contacts
Public ContactJun Yang
Xiang'an Hospital of Xiamen University
Outcome results
None listed