Postoperative Rehabilitation
Conditions
Interventions
Group 1:Intravenous injection of high dose esmolamine
Group 2:Intravenous injection of low dose esmolamine
Sponsors
Hwa Mei Hospital, University of Chinese Academy of Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients with moderate to severe burns; 2. Subjects of ASA grade II-III; 3. Subjects aged from 18 to 65, regardless of gender; 4. Subjects who are scheduled for debridement, escharectomy, skin transplantation of the same (different) species, autologous skin transplantation, skin flap transfer under general anesthesia; 5. Subjects with anxiety and / or depression symptoms were assessed by the scale.
Exclusion criteria
Exclusion criteria: 1. Patients with severe complications, mental illness, severe liver and kidney dysfunction, respiratory insufficiency, circulatory instability, etc; 2. Patients with inhalation injury, SpO2 < 90% or requiring mechanical ventilation; 3. Patients with elevated intraocular pressure (such as glaucoma) and elevated intracranial pressure; 4. Patients with sinus bradycardia, atrioventricular block and bundle branch block; 5. Patients with severe hypertension, coronary heart disease and diabetes mellitus; 6. Patients with poor compliance or drug abuse; 7. Patients allergic to the proposed drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brain-derived neurofactor;D-Serine;TNF-a;Interleukin-6; | — |
Countries
China
Contacts
Public ContactJin Weizheng
Ningbo Huamei hospital, University of Chinese Academy of Sciences
Outcome results
None listed