The effect of intravenous tranexamic acid on intraoperative visualization during surgery for high-grade chronic rhinosinusitis-a double-blind randomized controlled tria

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100043139

Enrollment

Unknown

Registered

2021-02-05

Start date

2021-03-01

Completion date

Unknown

Last updated

2021-05-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic sinusitis

Interventions

experimental group:Intravenous administration of tranexamic acid 15mg/kg before the beginning of operation

control group:normal saline

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Chronic sinusitis patients (CT Lund-Mackay score >= 12)aged 18-65 who underwent elective endoscopic sinus surgery.

Exclusion criteria

Exclusion criteria: 1) ASA grade greater than or equal to grade III; 2) BMI > 30; 3) previous history of thromboembolic disease; 4) allergy to tranexamic acid; 5) refusal to participate in this study; 6) long-term preoperative use of anticoagulants or antiplatelet drugs, or diagnosed as coagulation dysfunction.

Design outcomes

Primary

Measure	Time frame
Boezzart Score;	—

Secondary

Measure	Time frame
bleeding;Bleeding speed;numerical rating scale;Coagulation and fibrinolysis;	—

Countries

China

Contacts

Public ContactGuyan Wang

guyanwang2006@163.com+86 13910985139

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026