Dystonia
Conditions
Interventions
dystonia patients treated with DBS:Deep brain stimulation
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
7 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Diagnosis with dystonia; 2) Age at recruition ranges from 7 to 75 years old; 3) Meet one of the following conditions: a) Oral drugs can not effectively improve the motor symptoms, activities of daily living and severe pain of simple (idiopathic or hereditary) systemic dystonia, simple (idiopathic or hereditary) segmental dystonia, simple (idiopathic or hereditary) focal dystonia. b) Neurodegenerative diseases characterized by dystonia (systemic, segmental and focal) and with or without other symptoms of dyskinesia. c) The moderate and severe acquired dystonia with poor drug treatment effect mainly refers to delayed systemic, segmental and focal dystonia. 4) Those who can perform deep brain stimulation and cooperate with follow-up; 5) Willing to participate in clinical trials, and able to sign informed consent.
Exclusion criteria
Exclusion criteria: 1) Patients with severe (refractory) depression, anxiety, schizophrenia and other mental diseases, and the drug can not effectively control the mental symptoms; 2) There is obvious cognitive impairment, and this cognitive impairment is enough to affect the ability of daily life of patients; 3) There are obvious medical coexisting diseases affecting the operation or survival of patients; 4) Dopa responsive dystonia, paroxysmal dystonia and psychogenic dystonia; 5) Cardiac pacemaker, defibrillator, cochlear implant and other nerve stimulator have been implanted or need to be implanted; 6) Long term use of immunosuppressants or hormone therapy is required; 7) Having other types of diseases that need repeated MRI examination; 8) Unwilling or unable to cooperate with postoperative follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The severity of the disease;Laboratory inspection;Demography;Medical history;non-motor symptoms;imaging inspection; | — |
Countries
China
Contacts
Public ContactHuifang Shang
Department of Neurology, West China Hospital of Sichaun University
Outcome results
None listed