refractory depression
Conditions
Interventions
experimental group:Dilute Ketamine 0.25mg/kg in 50ml of 0.9% saline solution, and administer it slowly through intravenous infusion over 40 minutes, 3 times a week for 2 weeks, 6 times in total.
Sponsors
Zhongda Hospital, School of Medicine, Southeast University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18~60 years; 2. Right-handed; 3. Meet the DSM-5 and CCMD-3 diagnostic criteria for MDD; 4. Current course of disease (last onset) at least 2 weeks; 5. HAMD-24 score >= 18 points; 6. No clinical remission standard (HAMD reduction rate < 50%) was achieved after receiving at least two antidepressant treatments since onset. 7. No electroconvulsive therapy was received within half a year before inclusion.
Exclusion criteria
Exclusion criteria: 1. Comorbid another mental illness; 2. Have a history of alcohol/drug dependence or smoke > 10 per day; 3. Serious physical diseases of the heart, liver, kidney, brain and hematopoietic system, central nervous system infection, skull injury, epilepsy, multiple sclerosis, toxic metabolic disease, Parkinson's disease or intracranial tumors; 4. Family history of hereditary diseases; 5. Endocrine system diseases such as diabetes, hyperthyroidism or hypothyroidism; 6. Patients with suicidal intention.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HAMD reduction rate;treatment emergent symptom scale; | — |
Countries
China
Contacts
Public ContactYonggui Yuan
Zhongda Hospital, School of Medicine, Southeast University
Outcome results
None listed