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A multi-center clinical collaborative study on pharmacodynamic testing of Patient-Derived Tumor Xenograft (FastPDTX) to guide individualized treatment of neuroendocrine tumors

A multi-center clinical collaborative study on pharmacodynamic testing of Patient-Derived Tumor Xenograft (FastPDTX) to guide individualized treatment of neuroendocrine tumors

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100043124
Enrollment
Unknown
Registered
2021-02-05
Start date
2021-02-08
Completion date
Unknown
Last updated
2021-05-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

neuroendocrine tumor

Interventions

FastPDTX pharmacodynamic test group:Individualized chemotherapy

Sponsors

The First Affiliated Hospital with Nanjing Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: (1) Aged from 18 to 70 years, male or female; (2) Patients with relapsed and refractory neuroendocrine tumors diagnosed by histopathological examinations require anticancer drug treatment; (3) Be able to obtain fresh tumor tissue by surgical resection or biopsy; (4) With objective tumors that meet the RECIST 1.1 standard, CT/MRI can be used to evaluate the efficacy; (5) ECOG score 0~2, expected survival period must be >= 3 months; (6) Subjects participated voluntarily, signed an informed consent form, had good compliance, and were able to actively treat and cooperate with follow-up. Books, good compliance, can actively treat and cooperate with follow-up.

Exclusion criteria

Exclusion criteria: (1) At the same time participate in other drug clinical research; (2) Liver, kidney function and bone marrow hematopoietic function do not meet the requirements of chemotherapy; (3) Unwilling to use the anti-cancer drugs and/or programs recommended by the investigator in combination with the test results for subsequent chemotherapy after the failure of the previous treatment; (4) People suffering from severe uncontrolled acute infection or major organ diseases; (5) Women who are pregnant or breastfeeding.

Design outcomes

Primary

MeasureTime frame
ORR;DCR;Serum tumor markers;

Countries

China

Contacts

Public ContactTang Qi-Yun

The First Affiliated Hospital with Nanjing Medical University

tqy831@163.com+86 25-68306360

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026