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Clinical value of combined detection of REG3A, I-FABP and nCD64 in the early diagnosis of neonatal necrotizing enterocolitis

Clinical value of combined detection of REG3A, I-FABP and nCD64 in the early diagnosis of neonatal necrotizing enterocolitis

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100043104
Enrollment
Unknown
Registered
2021-02-05
Start date
2019-04-30
Completion date
Unknown
Last updated
2021-05-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Necrotizing enterocolitis

Interventions

Gold Standard:NEC diagnosis and severity index: The diagnosis and staging of NEC were based on the modified Bell's grading criteria
Index test:Serum&#32
regeneration&#32
family&#32
member&#32
3&#32
alpha&#32
gene,&#32
Intestinal&#32
fatty&#32
acid&#32
binding&#32
protein,&#32
Neutrophil&#32
CD64&#32

Sponsors

Department of General Surgery, Shanghai Children's Hospital, Shanghai Jiao Tong University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
No minimum to 0.1 Years

Inclusion criteria

Inclusion criteria: 1. Preterm infants admitted from April 2019 to December 2021 were collected prospectively; 2. Preterm infants with gestational age < 32 weeks or birth weight < 1500g were included.

Exclusion criteria

Exclusion criteria: 1. Patients with congenital intestinal diseases; 2. Patients with congenital abdominal wall defect; 3. Patients with complex deformities.

Design outcomes

Primary

MeasureTime frame
Serum regeneration family member 3 alpha gene;Intestinal fatty acid binding protein;Neutrophil CD64;SEN, SPE, ACC, AUC of ROC;—

Countries

China

Contacts

Public ContactWeijue Xu

Department of General Surgery, Shanghai Children's Hospital, Shanghai Jiao Tong University

xuweijue@shchildren.com+86 18917128075

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026