Acute Ischemic Stroke/Transient Ischemic Attack
Conditions
Interventions
Group 1:Clopidogrel with Indobufen
Group 2:Clopidogrel with Aspirin
Sponsors
The Fifth Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: (1) Aged 18 or above. (2) First onset. (3) Patients with acute non-cardiac TIA or mild ischemic stroke (NIHSS score = 4) within 72 hours of onset, or patients with severe symptomatic intracranial artery stenosis (stenosis rate 70%-99%) within 1 month of onset. (4) The patient or his/her family signed the informed consent.
Exclusion criteria
Exclusion criteria: (1) Vascular malformation, tumor, abscess or other ischemic cerebrovascular diseases not caused by atherosclerosis. (2) Isolated sensory symptoms (such as numbness), isolated visual changes, or isolated dizziness or vertigo, but no evidence of acute infarction on baseline CT or MRI of the head. (3) A score of more than 2 on the modified Rankin scale prior to the occurrence of acute ischemic stroke or TIA. (4) There are clear indications of anticoagulant therapy (assumed cardiac source of emboli, such as atrial fibrillation or artificial heart valves). (5) History of intracranial hemorrhage; The anticipated demand for long-term non-investigational antiplatelet drugs or NSAIDs that affect platelet function. (6) Heparin therapy or oral anticoagulant therapy were given within the first 10 days of randomization. (7) gastrointestinal bleeding or major surgery within the first 3 months. (8) Planned or possible revascularization (any angioplasty or vascular surgery) within 3 months after screening (angiography should be performed prior to randomization if clinical indications are available). (9) Need to stop the study of drugs planned surgery or interventional therapy. (10) TIA or minor stroke caused by angiography or surgery. (11) Have a serious non-cardiovascular coexisting disease and a life expectancy of less than 3 months. (12) Women of child-bearing age who do not use reliable contraceptives, who have no documented negative pregnancy tests, and who receive other study drugs or devices. (13) Indobuprofen, aspirin and clopidogrel were contraindicated.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recurrence rate of stroke;Modified Rankin Scale; | — |
Countries
China
Contacts
Public ContactLei Zhang
The Fifth Affiliated Hospital of Sun Yat-Sen University
Outcome results
None listed