esophageal squamous cell carcinoma
Conditions
Interventions
Sponsors
Shanxi Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients with stage Ib~?a esophageal squamous cell carcinoma (ESCC) who are unresectable or have surgical contraindications or refuse surgery; 2. Have not received any treatment before; 3. Age 18-75 years old, both male and female; 4. ECOG: 0~2; 5. The estimated survival time exceeds 6 months; 6. The functions of vital organs meet the following requirements (no blood components and cell growth factors are allowed to be used 2 weeks before the start of research and treatment): a. Absolute neutrophil count (ANC) >= 1.5 x 10^9/L; b. Platelets >= 100 x 10^9/L; c. Hemoglobin >= 9 g/dL; d. Serum albumin >= 2.8 g/dL; e. Bilirubin = 50mL/min; 6. Female subjects with fertility should undergo a urine or serum pregnancy test within 72 hours before receiving the first study drug administration and prove to be negative, and are willing to use effective methods of contraception during the trial. For male subjects whose partners are women of childbearing age, effective methods of contraception should be used during the trial; 7. The researcher determined that the patient can receive radiotherapy without contraindications to radiotherapy; 8. The subjects voluntarily joined the study, signed an informed consent form, had good compliance, and cooperated with the follow-up.
Exclusion criteria
Exclusion criteria: 1. Other malignant tumors have been diagnosed within 5 years before the first use of the research drug, except for effectively treated skin basal cell carcinoma, skin squamous cell carcinoma, and/or effectively resected in situ cervical cancer and/or breast cancer; 2. Symptomatic brain metastases; 3. Have received other anti-tumor drug treatment in the past; 4. Poor general condition, accompanied by cachexia, poor cardiopulmonary function or serious diseases of other vital organ systems, and cannot tolerate radiotherapy; 5. There are signs of esophageal hemorrhage or hemorrhage; 6. Esophageal fistula combined with severe infection; 7. Women during pregnancy or lactation; 8. The blood or tissue sample is unqualified; According to the judgment of the investigator, the subject has other factors that may cause him to be forced to terminate the study, such as suffering from other serious diseases (including mental illness) requiring combined treatment, severely abnormal laboratory test values, family or social factors, which may affect to the safety of subjects or the collection of experimental data.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Full exome and transcriptome information; | — |
Countries
China
Contacts
Public ContactHongwei Li
Shanxi Cancer Hospital
Outcome results
None listed