Multiple myeloma
Conditions
Interventions
single arm:BRD-lite
Sponsors
The First Affiliated Hospital of Kunming Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Patients with symptomatic myeloma, organ damage related to myeloma; 2. Patients with myeloma can be measured by monoclonal antibody components in serum or urine or free light chain in serum; 3. Those patients who can promise to completely terminate sexual contact with the opposite sex, or start birth control.
Exclusion criteria
Exclusion criteria: 1. The patients who are qualified for autologous stem cell transplantation should be evaluated by comprehensive consideration of physical condition, concurrent diseases and other factors; 2. HIV positive patients with antiretroviral therapy; 3. Pregnant or lactating subjects; 4. Patients who have received any systemic anti myeloma therapy before; 5. Patients with primary amyloidosis or myeloma complicated with amyloidosis; 6. Patients who received other regimens within 14 days or during the period of enrollment; 7. Patients with known brain metastases; 8. Subjects with poor tolerance or known allergy to any of the research drugs or similar compounds; 9. Subjects with history of other malignant diseases except basal cell carcinoma or stage I cervical carcinoma; 10. Subjects who could not comply with the antithrombotic treatment protocol; 11. Subjects with peripheral neuropathy >= grade 2.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| objective response rate; | — |
Countries
China
Contacts
Public ContactMingxia Shi
The First Affiliated Hospital of Kunming Medical University
Outcome results
None listed