Perioperative neurocognitive disorders, PND
Conditions
Interventions
Control group:Does not accept lidocaine intravenous infusion during the perioperative period
Experimental group:Receive 3 intravenous infusions of lidocaine during the perioperative period
Sponsors
Fujian Provincial Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients over 65 years old; 2. Subjects requiring 3 or more general anesthesia operations within 30 days; 3. ASA I-III subjects; 4. Patients who voluntarily cooperate with follow-up and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients who did not understand or refused the test method; 2. Patients allergic to lidocaine; 3. Patients with a history of alcohol abuse, psychiatric and anticholinergic drug abuse; 4. Patients with preoperative Mini Mental State Examination (MMSE) score 35kg / m2; 6. Patients with a history of mental disorders or nervous system diseases (including Alzheimer's disease and stroke history); 7. Patients with history of severe anemia and liver and kidney dysfunction; 8. Patients with severe visual and hearing impairment; 9. Patients whose average life span is less than 6 months; 10. Patients with diseases or conditions considered by other researchers not to be included.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnosis of PND;brain-derived neurotrophic factor, BDNF;S100ß protein;neuron-specific enolase, NSE; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual Analogue scale, VAS;Total consumption of propofol during surgery;Total consumption of remifentanil during surgery;Time required for consciousness recovery after surgery;Time to remove tracheal tube after surgery;Time spent in PACU;Sore throat after surgery;Nausea and vomiting after surgery;Thrombus;Rehabilitation index;Interleukin- 6;Interleukin-8;C-reactive protein, CRP; | — |
Countries
China
Contacts
Public ContactXiaochun Zheng
Fujian Provincial Hospital
Outcome results
None listed