type 2 diabetes mellitus
Conditions
Interventions
Newly diagnosed obese T2DM with FMT:Fecal microbiota transplantation
Newly diagnosed obese T2DM with FMT+diet management:Fecal microbiota transplantation+diet management
Newly diagnosed obese T2DM with diet management:Diet management
Treated diagnosed obese T2DM with FMT:Fecal microbiota transplantation
Normal control group:No
Sponsors
Changzhou 2nd People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Meet the 2019 American Diabetes Association (ADA) diagnosis of type 2 diabetes (T2DM); 2. Diabetes course <=6 years; 3. BMI 28-45kg/m2; 4. Volunteer to participate in the trial and sign an informed consent form; 5. patients aged 18-50 years old.
Exclusion criteria
Exclusion criteria: 1. Acute and chronic infectious diseases, gastrointestinal diseases, severe heart insufficiency, severe liver and kidney insufficiency and other diseases or complications; 2. People with other gastrointestinal diseases that may affect drug absorption; 3. Patients with malignant tumors in the past 2 years; 4. Patients who cannot tolerate gastroscopy; 5. Pregnant and lactating women; 6. People with allergies; 7. Patients who have used weight-loss drugs in the past year; 8. Patients using other hormone therapy in the past 3 months; 9. Patients who have used antibiotics or probiotics in the past 3 months; 10. Cardiovascular and cerebrovascular diseases occurred newly in the past 3 months; 11. Participate in other clinical trials during the same period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HbA1c; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood lipid;Intra-abdominal fat;Fecal microbiota;Bile acid;Fasting blood glucose;Free fatty acid;Liver fat content;Blood glucose fluctuations;Islet function;Short chain fatty acids;Inflammatory factors; | — |
Countries
China
Contacts
Public ContactShi Li
Changzhou 2nd People's Hospital
Outcome results
None listed