Neuromyelitis optica spectrum diseases
Conditions
Interventions
low dose rituximab group: low dose rituximab
Sponsors
Shandong University Qilu Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. They met the diagnostic criteria of neuromyelitis optica spectrum disease (nmosd) with AQP4 antibody positive in 2015; 2. They were 18-70 years old; 3. The patient's condition was in the acute stage of relapse, that is, there were new neurological deficit symptoms within 30 days before screening, or the original symptoms worsened, and the symptoms lasted for at least 24 hours without accompanying fever; 4. Disability: EDSS <=7.0; 5. The subjects or their legal representatives voluntarily signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Pregnant women, lactating women and patients with family planning in recent 24 months; 2. Patients receiving rituximab; 3. Human immunoglobulin or other immunosuppressants (such as mycophenolate mofetil, cyclophosphamide, azathioprine, methotrexate, etc.) are being used to affect the efficacy evaluation of drugs, and the withdrawal period is less than 5 half lives; 4. Suffering from uncontrolled acute infection or chronic infection unsuitable for immunosuppressive drugs, such as active hepatitis B or C, tuberculosis, HIV, etc.; 5. Due to severe mental or language disorders, it is impossible to complete the clinical trial or meet the follow-up requirements; 6. Due to serious cardiovascular disease, blood / hematopoietic system disease, respiratory system disease, endocrine disease, kidney / urinary system disease, digestive system disease, congenital or acquired severe immunodeficiency, malignant tumor and other diseases; 7. The researcher thinks that it is not suitable to participate in this clinical trial for other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| vision;visual field;the fundus oculi;Brain magnetic resonance imaging;Magnetic resonance imaging of spinal cord;Magnetic resonance imaging of optic nerve;physical examination;EDSS scale; | — |
Countries
China
Contacts
Public ContactShenjun Wang
Qilu Hospital of Shandong University
Outcome results
None listed