Refractory Peptic Ulcer Disease
Conditions
Interventions
The experimental group:PPI8 weeks + mucosal protectant 8 weeks +HBOT20 times
The control group:PPI8 weeks + mucosal protectant 8 weeks
Sponsors
Shenzhen People's Hospital
Eligibility
Sex/Gender
All
Age
16 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients diagnosed with RPUD in our hospital between February 2021 and December 2021. (1) Age above 16, male or female. (2) Peptic ulcer was found by electronic gastroscopy, and pathological biopsy was performed to rule out malignant changes of ulcer. (3) Routine PPI treatment (DU8 weeks, GU12 weeks). (4) Patients with Hp infection, Hp turned negative after Hp eradication, but the ulcer was still not healed. (5) Agree to receive hyperbaric oxygen treatment and sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) Gastrinoma. (2) People with severe heart and lung disease, nervous system disease, shock, coma and other intolerant diseases. (3) Patients who could not tolerate hyperbaric oxygen therapy. (4) After hyperbaric oxygen treatment, there are obvious side effects, such as vision loss, muscle twitching, epileptic seizure, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ulcer area;Ulcer healing rate;Recurrence rate of ulcers;Treatment complication rate;Abdominal pain score; | — |
Countries
China
Contacts
Public ContactZhenglei Xu
Shenzhen People's Hospital
Outcome results
None listed