cognition impairment
Conditions
Interventions
Group A:In group A, 0.05 mg/kg midazolam was injected intravenously 10 minutes before induction, and 0.5 µg/(kg·min) midazolam was continuously pumped after tracheal intubation to 30 minutes before th
Group B:Intravenous injection of dexmedetomidine at 1ug/kg was performed before anesthesia induction for 10min. Then, the infusion was maintained at 0.2 g/(kg·h) until the infusion was stopped 30min b
Group C:Intravenous injection of dexmedetomidine at 0.5ug/kg was performed before anesthesia induction for 10min. Then, the infusion was maintained at 0.2 g/(kg·h) until the infusion was stopped 30min
Group D:Intravenous injection of dexmedetomidine at 0.25ug/kg was performed before anesthesia induction for 10min. Then, the infusion was maintained at 0.2 g/(kg·h) until the infusion was stopped 30mi
Sponsors
Women and Children's Hospital, School of Medicine, Xiamen University
Eligibility
Sex/Gender
Female
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Estimated survival time of patients was more than 3 months, and ASA was grade I-II. 2.Patients without respiratory complications. 3.Approved by the ethics committee of this hospital, the ethics number is KY-2020-057. 4.Patients and their family members agreed and cooperated with this study, and signed an informed agreement.
Exclusion criteria
Exclusion criteria: 1. Patients have contraindication to dexmedetomidine. 2. Patients have severe heart, liver and kidney dysfunction. 3. Patients have nervous system and mental illness. 4. Patients have undergone long-term analgesia and sedation before operation. 5. Patients have contraindications to laparoscopic operation. 6. Blind or deaf people are difficult to evaluate by cognitive score. Sixth, 7. Patients have poor compliance, withdrawing halfway through.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MoCA (Montreal Cognitive Assessment Scale) score;MMSE (Simplified Mental State Scale) score;TNF- (tumor necrosis Factor -a);IL-6;S - 100 protein beta;NSE;GFAP;Intraoperative dosage of Remifentanil, sufentanil, propofol,;Resuscitation room stay time, anesthesia extubation time and anesthesia recovery time; | — |
Countries
China
Contacts
Public ContactJunxiang Jia
Women and Children's Hospital, School of Medicine, Xiamen University
Outcome results
None listed