Airway management
Conditions
Interventions
Remifentanil alone:Infusion of remifentanil
Remifentanil combined with remimazolam 0.2:Combined infusion of remifentanil and remimazolam
Remifentanil combined with remimazolam 0.4:Combined infusion of remifentanil and remimazolam
Remifentanil combined with remimazolam 0.6:Combined infusion of remifentanil and remimazolam
Remimazolam alone:Infusion of remimazolam
Sponsors
Beijing Friendship Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Patients undergoing elective surgery under general anesthesia with endotracheal intubation,aged 18-60 years old, ASA 1-2, and predicted operation time >= 2 h.
Exclusion criteria
Exclusion criteria: Pregnant and lactating women, BMI >= 30, severe cardiopulmonary disease, bradycardia, hypotension, a history of drug and/or alcohol abuse, allergy to study drugs;incooperative patients with mental retardation or mental disorders and refusal to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bispectral index;Modified Observers' Assessment of Alertness/Sedation scale;Reaction to placement of the fiberoptic scope and endotracheal tube;Cough severity;Tolerance to the endotracheal tube in the trachea;Intubation time;Lidocaine requirements;Recall of the procedure;Willingness to accept the procedure again; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure;Heart rate;Pulse oximetry;Complications such as deep sedation and respiratory depression;The first partial pressure of end-tidal CO2 after intubation; | — |
Countries
China
Contacts
Public ContactChengwen Li
Beijing Friendship Hospital, Capital Medical University
Outcome results
None listed