Acute Myocardial Infartion
Conditions
Interventions
Intracoronary thrombolysis group:20mg of recombinant human urokinase was injected into the proximal end of intracoronal thrombus
thrombus aspiration group:routine method of thrombus aspiration
Sponsors
The Fourth Affiliated Hospital of Harbin Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged from 18 to 75 years (including 18 and 75 years old) are not limited in gender; 2. Patients with symptoms less than 12 hours, indications for thrombolysis and exclusion of contraindications for thrombolysis; 3. Patients who can understand and sign informed consent voluntarily.
Exclusion criteria
Exclusion criteria: 1. Patients with suspected aortic dissection; 2. Patients with history of intracranial hemorrhage; 3. Patients with ischemic stroke within 3 months; 4. Severe head and face injury within 3 months; 5. Patients with active bleeding or bleeding factors (including menstruation); 6. Patients with severe trauma or major operation or vascular bleeding that cannot be compressed within 3 weeks; 7. Patients with severe or uncontrolled hypertension (SBP > 180mmhg or DBP > 110mmhg); 8. Patients who have undergone rescue PCI with intravenous thrombolysis; 9. Pregnant women, lactating women or women who are likely to be pregnant; 10. Patients who are known to be allergic to the study drug or contrast agent or have contraindications; 11. Patients after CABG; 12. Patients with severe hepatic and renal insufficiency; 13. Patients with malignant tumor; 14. Patients taking anticoagulants for a long time (such as warfarin, rivaroxaban, etc.); 15. Patients whose coronary angiography showed TIMI grade 3 of culprit vessel flow without obvious thrombus sign; 16. Patients who participated in other clinical studies at the same time; 17. The researcher thinks that it is not suitable for the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiovascular death within 180 days;recurrent AMI within 180 days;cardiogenic shock within 180 days;New or aggravated NYHA IV heart failure within 180 days; | — |
Secondary
| Measure | Time frame |
|---|---|
| (TIMI Myocardial Blush Grades, MBG) after PCI;TIMI Myocardial Perfusion Grade, TMPG after PCI;TIMI flow grades;Corrected TIMI Frame Count, cTFC;The ST segment resolution after PCI; | — |
Countries
China
Contacts
Public ContactWei Yang
The Fourth Affiliated Hospital of Harbin Medical University
Outcome results
None listed