Head and Neck Squamous Cell Carcinoma
Conditions
Interventions
Gold Standard:RECIST Version 1.1
magnetic 
resonance 
imaging 
of 
and 
Sponsors
First Medical Center of Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. In patients with HNSCC, the primary sites included pharynx (including nasopharynx, oropharynx, hypopharynx), larynx, nasal cavity and paranasal sinuses; 2. Patients with definite pathological diagnosis and clinical staging of locally advanced tumors (according to AJCC 8th Edition head and neck tumor staging criteria: T1-4 N2-3 M0 but not T1-2 N1 M0, T3-4 n0-1 M0); 3. For subjects with KPS score >= 70, ECoG score: 0-1; 4. Subjects aged 18-70 years old; 5. Subjects who can tolerate plain and enhanced MRI examination; 6. Imaging examination (plain MRI + enhanced MRI); The range of primary lesion invasion and lymph node metastasis were confirmed by color Doppler ultrasound (CDFI); 7. Subjects with normal liver and kidney function, without severe hematologic toxicity and severe medical complications, were allowed to participate in induction chemotherapy, concurrent chemotherapy, consolidation chemotherapy, targeted therapy and other treatment methods; 8. Subjects without surgical intervention; 9. Volunteers who signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients over 70 years old; 2. For patients whose KPS score was less than 70, ECoG score was more than 1; 3. Patients with liver and kidney dysfunction, severe hematologic toxicity and medical complications can not be treated with induction chemotherapy or synchronous chemotherapy; 4. Patients with previous head and neck radiotherapy history; 5. Patients with denture, prosthesis and other metal implants; 6. Claustrophobic patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ADC;MD/MK;IVIM (Dslow/Dfast/PF);DCE-MRI (Ktrans/Ve/Kep); | — |
Countries
China
Contacts
Public ContactLin Ma
Department of Radiotherapy, First Medical Center, General Hospital of Chinese People's Liberation Army
Outcome results
None listed