Breast Cancer
Conditions
Interventions
36.5Gy/10F group:Nil
50Gy/25F group:Nil
Sponsors
The First Medical Center of Chinese PLA General Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. The subjects who voluntarily participated and signed the informed consent in writing; 2. Female, aged 18-70 years; 3. Patients with stage IIA (excluding T2N0) - IIIc breast cancer were pathologically invasive; 4. Patients after modified radical operation; 5. Patients receiving chemotherapy, endocrine therapy or targeted therapy as planned; 6. Patients with axillary lymph node metastasis diagnosed by pathology, and invasive cancer patients with modified radical operation after neoadjuvant chemotherapy; 7. Subjects with normal blood routine, liver and kidney function; 8. Patients with Karnofsky score >= 80 had an expected survival period of more than 12 months; 9. Subjects without serious underlying diseases of heart and lung.
Exclusion criteria
Exclusion criteria: 1. Patients whose operation time is more than 8 months from the beginning of adjuvant radiotherapy; 2. HER-2 positive patients without targeted therapy; 3. Patients who did not complete postoperative adjuvant chemotherapy as planned; 4. Er / PR positive patients without postoperative adjuvant endocrine therapy; 5. Patients with distant metastasis; 6. Patients with previous radiotherapy history in the area to be irradiated; 7. Patients with active connective tissue disease in the treatment area; 8. Patients with severe comorbidities and psychiatric history; 9. Patients who refused or could not sign the informed consent to participate in the trial; 10. Patients with expected survival less than 12 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| locoregional relapse; | — |
Secondary
| Measure | Time frame |
|---|---|
| overal survival;disease-free survial;acute side effects;late side effects; | — |
Countries
China
Contacts
Public ContactLin Ma
Department of Radiation Oncology, First Medical Center of Chinese PLA General Hospital
Outcome results
None listed