Comparison of the therapeutic effects of fractional CO2 laser, pulsed dye laser and photodynamic therapy on 2 cases of necrobiosis lipoidica

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100042848

Enrollment

Unknown

Registered

2021-01-30

Start date

2021-02-01

Completion date

Unknown

Last updated

2021-05-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

necrobiosis lipoidica

Interventions

experimental group:fractional CO2 laser therapy, pulsed dye laser therapy, and photodynamic therapy

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients with a pathological diagnosis of necrobiosis lipoidica; 2. Patients with poor response to conventional therapies; 3. Patients with good compliance and able to participate regularly in follow-up visits.

Exclusion criteria

Exclusion criteria: 1. Patients with severe photosensitivity reactions; 2. Patients with severe cardiovascular and cerebrovascular diseases, liver and kidney diseases, hematopoietic system diseases, mental diseases and immunodeficiency diseases; 3. Pregnant or lactating women; 4. Allergic to the test drug and its components; 5. Researchers participating in other clinical trials; 6. The researcher thinks that it is not suitable to participate in this research.

Design outcomes

Primary

Measure	Time frame
General photo evaluation;Subjective evaluation of patients;Changes in hydration, transcutaneous water loss, melanin value, and erythema value of the skin at the same site;Epidermal and dermal thickness,Local blood supply;Changes of blood vessels and pigment in the same part;	—

Countries

China

Contacts

Public ContactZhuo Fenglin

Beijing Friendship Hospital affiliated to Capital Medical University

770972657@qq.com+86 15910895068

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026