Nonerosive reflux disease
Conditions
Interventions
The NERD group:Stretta treatment
Healthy Subjects:There are no interventions
Sponsors
Suining Central Hospital
Eligibility
Sex/Gender
All
Age
19 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18 and 75 years; 2. 24-hour pH monitoring indicates pathological acid reflux; 3. The course of disease is more than 1 year, responsiveness to PPIs, and PPI should be taken at least 3 times a day or at least 3 times a week to control reflux symptom control; 4. Endoscopically evidenced gastroscopy gastroesophageal reflux disc grade (GEFV grade) grade 2-3; 5. Lower than normal LES pressure(LES pressure lower than 15mmHg) detected by high-resolution esophageal manometry; 6. Willing to participate in this study and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Sliding hiatal hernia > 3cm; 2. Endoscopically evidenced esophagitis or Barrett esophagus; 3. Suffering from other digestive system-related diseases, such as decompensated cirrhosis, acute / chronic pancreatitis, Zollinger-Ellison syndrome, malignant tumor, etc.; 4. Previous upper gastrointestinal surgery; 5. Endoscopically evidenced other positive lesions not related to GERD, such as esophageal varices, esophageal and or gastric malignant tumors, ulcers, etc. 6. Severe cardiopulmonary insufficiency or other diseases may cause the patient to be unable to tolerate relevant examination or treatment; 7. Pregnant.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lower esophageal sphincter Thickness;Lower esophageal sphincter pressure;DeMeester score;SF-36 Health Survey score; | — |
Countries
China
Contacts
Public ContactSuyu He
Suining Central Hospital
Outcome results
None listed