Refractory and relapsed acute T lymphocytic leukemia
Conditions
Interventions
Sponsors
Beijing Boren Hospital
Eligibility
Sex/Gender
All
Age
1 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Acute T-lymphocytic leukemia (T-ALL) diagnosed as CD4 marker-positive, hematological recurrence during chemotherapy, or recurrence or primary drug resistance after bone marrow transplantation, or hematological recurrence after drug withdrawal (standard reference NCCN, 2015.2); 2. Aged 1-70 years; 3. Morphological examination of primitive and naive lymphocytes = 18 years of age are self-aware and able to sign informed and voluntary consent forms; The guardian of the pediatric patient or the patient's entruster signed the informed and voluntary consent form to join the trial.
Exclusion criteria
Exclusion criteria: 1. Intracranial hypertension or unconsciousness; 2. Symptomatic heart failure or severe arrhythmia; 3. Respiratory failure; 4. With other types of malignant tumors; 5. CD4-negative hematological tumors; 6. Diffuse intravascular coagulation; 7. Serum creatinine and/or urea nitrogen >= 1.5 times the normal value; 8. Sepsis or other infections that are difficult to control; 9. Uncontrollable diabetes; 10. Severe mental disorder; 11. There are obvious lesions in the skull by MRI of the head; 12. Cerebrospinal fluid examination for leukemia cells > 20/ul; 13. The proportion of blood leukemia cells > 30%; 14. WHO physical status classification >= 3; 15. Organ transplant recipients; 16. Pregnant and lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Safety evaluation index;Pharmacokinetic evaluation index;Curative effect evaluation index; | — |
Countries
China
Contacts
Public ContactDefeng Zhao
Beijing Boren Hospital
Outcome results
None listed