Major Depressive Disorder
Conditions
Interventions
active integrated Acupuncture and Moxibustion+placebo:active integrated Acupuncture and Moxibustion+placebo 50mg/qd
active integrated Acupuncture and Moxibustion+Sertraline:active integrated Acupuncture and Moxibustion+Sertraline 50mg/qd
sham integrated Acupuncture and Moxibustion+Sertraline:sham integrated Acupuncture and Moxibustion+Sertraline 50mg/qd
sham integrated Acupuncture and Moxibustion+placebo:sham integrated Acupuncture and Moxibustion+placebo 50mg/qd
Healthy volunteers:acupuncture
Sponsors
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria of Chinese and Western medicine; 2. Aged 18-65 years, junior high school (inclusive) and above; 3. The 17-item Hamilton Depression Scale (HAMD17) score > 17, <= 24 points; 4. Right handed; 5. Those who sign an informed consent and voluntarily participate in this research. Those who meet the above 5 items can be included in the study.
Exclusion criteria
Exclusion criteria: 1. Persons with suicidal tendency; 2. Previously diagnosed with mental disorders, schizophrenia, bipolar disorder, substance abuse (such as alcohol dependence) or other mental disorders; 3. Patients with a history of epileptic seizures or a family history of strong positive epilepsy, a history of brain organic diseases and severe physical diseases; 4. Those who are taking antidepressants within 6 weeks (including 6 weeks); 5. Pregnancy, pregnancy or lactation period; 6. Syndrome patients with skin lesions or skin diseases, severe diabetes, tumors and vital organ dysfunction, or severe liver, kidney, cardiovascular, endocrine, respiratory, and hematopoietic diseases 7. MRI examination contraindications such as pacemaker, cardiac stent, claustrophobia, etc.; 8. Other patients with central or peripheral neuropathy. Those who meet any of the above will be excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional Magnetic Resonance Imaging(fMRI); | — |
Secondary
| Measure | Time frame |
|---|---|
| Electroencephalogram(EEG);Hamilton Depression Scale 17-item version (HAMD-17);Patient Health Questionnaire 9-item version (PHQ-9);Hamilton Anxiety (HAMA) scales;Pittsburgh Sleep Quality Index (PSQI);dynamic cerebral autoregulation; | — |
Countries
China
Contacts
Public ContactWenbin Fu
The Second Affiliated Hospital of Guangzhou University of traditional Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine
Outcome results
None listed