Population-based exome sequencing arrests frequent and de novo mutations in high myopia

Study of Methods for Early Diagnosis and Individualized Treatment of Myopia

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2100042758

Enrollment

Unknown

Registered

2021-01-27

Start date

2018-01-01

Completion date

Unknown

Last updated

2021-05-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

myopia

Interventions

Emmetropia or low myopia control group:No intervention

High myopia group:No intervention

Pathological myopia group:No intervention

Eligibility

Sex/Gender

All

Age

4 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Inclusion criteria for emmetropia or low myopia control group: (1) Meet the above diagnostic criteria above; (2) Sign informed consent; (3) With normal corrected vision; (4) Without any other organic eye diseases. 2. Inclusion criteria for High myopia group (1) With at least one eye meeting the above clinical diagnostic criteria; (2) Sign informed consent. 3. Inclusion criteria for pathological myopia group: (1) Meets the above diagnostic criteria; (2) Sign informed consent.

Exclusion criteria

Exclusion criteria: 1. Exclusion criteria for emmetropia or low myopia control group: (1) Unwilling to join or continue the study; (2) Cannot cooperate well to the study due to poor mental state. 2. Exclusion criteria for High myopia group: (1) Exclude systemic diseases caused other eye impacts, such as hypertensive retinopathy, diabetic retinopathy and so on; (2) Psychopath; (3) Those who cannot cooperate with the investigation. 3. Exclusion criteria for pathological myopia: (1) Those who are unwilling to join the study; (2) Those who cannot cooperate well due to poor mental state; (3) With congenital hereditary eye diseases, such as ametropia caused by congenital scleral abnormalities, adhesive leukoplakia, lens abnormalities and so on; (4) With other systemic organic diseases or a history of major previous operations.

Design outcomes

Primary

Measure	Time frame
diopter;axial length;	—

Secondary

Measure	Time frame
uncorrected vision;corrected vision;intraocular pressure;corneal curvature;Optical coherence tomography;Fundus photography;	—

Countries

China

Contacts

Public ContactBi Hongsheng

Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine

hongshengbi@163.com+86 13953113696

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026