hepatocellular carcinoma
Conditions
Interventions
Intervention group:intravenous lidocaine Infusion
Sponsors
Department of Anesthesiology, Affiliated Hospital of North Sichuan Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Patients undergoing laparoscopic hepatectomy for hepatocellular carcinoma; 2.Aged 18-65 years; 3.American Society of Anesthesiologists (ASA) physical status classification I-III level patients; 4.BMI:18-30kg/m2.
Exclusion criteria
Exclusion criteria: 1.Severe hepatitic or renal dysfunction(total bilirubin > 1.46mg/dl, glomerular filtration rate < 30ml/min /1.73? or end-stage renal disease); 2.Severe heart disease(severe heart block, Sinus bradycardia; Patients with Adams-Stokes syndrome, preexcitation syndrome, etc); 3.Allergy to lidocaine; 4.Long-term use of drugs that affect lidocaine metabolism such as cimetidine and beta blockers; 5.Combined other malignant tumors; 6.Tumor invasion in the portal vein, hepatic vein, or inferior vena cava; 7.Patients with a history of seizures;8,patients who had taken other experimental drugs or were participating.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma concentration of lidocaine;maximum peak concentration of the drug in plasma(Cmax);time to reach maximum concentration(Tmax);terminal elimination half-life(t1/2);clearance rates;Volume of distribution;area under the curve (AUC)from time zero to infinity;AUC0-t;Elimination rate constant;AUC_%Extrap; | — |
Secondary
| Measure | Time frame |
|---|---|
| central venous pressure; intraoperative blood loss, transfused blood products, intraoperative crystalline or colloidal infusion volume; | — |
Countries
China
Contacts
Public ContactFaping Tu
Department of Anesthesiology, Affiliated Hospital of North Sichuan Medical College
Outcome results
None listed