Depression
Conditions
Interventions
experimental group:Probiotic Yogurt
control group:placebo
Sponsors
Beijing Huilongguan Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 59 Years
Inclusion criteria
Inclusion criteria: 1. Han nationality; 2. Hamilton Depression Scale (HAMD-24) >= 20 points; 3. Aged 18-59 years; 4. Right-handed; 5. The patient is taking sertraline hydrochloride/escitalopram oxalate.
Exclusion criteria
Exclusion criteria: 1. Suffer from HIV/AIDS, cancer or undergoing chemotherapy; 2. Crohn's disease, ulcerative colitis, lactose intolerance or gluten intolerance; 3. If the participant is currently experiencing severe depressive symptoms, they are also excluded (quantified as a HAMD score higher than 35). Or are at risk of suicide/self-harm, be diagnosed with bipolar disorder or personality disorder, mental illness or other mental illness; 4. People at high risk of drinking (males drink 20 glasses per week, women drink 12 glasses per week. 1 standard glass is approximately equal to 360g beer or 100g wine or 30g liquor); 5. Currently undergoing trial or taking antibiotics or probiotic supplements within two weeks, or using antibiotics or probiotics within 4 weeks before joining the group; 6. Women who are pregnant or plan to become pregnant during the trial period; 7. Currently participating in another study (such as other interventional studies or studies affecting the intestinal flora); 8. Those with cognitive dysfunction or unable to take care of themselves; 9. The investigator considers other patients not suitable for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HAMD; | — |
Secondary
| Measure | Time frame |
|---|---|
| HAMA;TESS;PAC-SYM;CGI;PSQI;FTND;PSP;SQLS;MCCB;WHOQOL—BREF; | — |
Countries
China
Contacts
Public ContactPang Yu
Beijing Huilongguan Hospital
Outcome results
None listed