Skin disease
Conditions
Interventions
1:Bariatric surgery
Sponsors
Xiangya Third Hospital of Central South University
Eligibility
Sex/Gender
Male
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Subjects aged from 20 to 60 years old (including 20 and 60 years old); 2. The subjects whose body mass index (BMI) is above 27.5 kg / m2, whose lifestyle changes and medical treatment are difficult to control, meet at least two diagnostic criteria of metabolic syndrome, or have other complications; 3. Women of childbearing age should use an effective method for contraception at least one month before screening, and agree to use this method for contraception during the study period and at least one year after surgery; 4. Waist circumference >= 90cm for male and >= 85CM for female; 5. Patients with skin diseases, including acanthosis nigricans, psoriasis, acne or hirsutism, etc; 6. Patients or guardians fully understand that this is a clinical trial and voluntarily participate in it. They are willing to return visit within the specified time to assist in the completion of the trial.
Exclusion criteria
Exclusion criteria: All subjects who meet one of the following conditions can not be included in the trial: 1. Subjects with a history of drug and / or alcohol abuse within 2 years; Those with mental retardation and uncontrollable behavior; 2. Subjects who are unwilling to cooperate with the changes of diet and living habits after operation; 3. Patients with severe kidney disease, uncontrolled hypertension (>= 150 / 100mmhg), symptomatic ischemic heart disease, cerebral infarction or arteriosclerosis obliterans, malignant tumor, poor general condition, difficult to tolerate general anesthesia and surgery; 4. Patients with previous gastrointestinal surgery (such as surgery involving gastrointestinal resection), or invasive medical intervention, such as colonoscopy, 3 months before sampling (feces); The diet changed significantly one week before sampling; Female in physiological stage; Patients with other intestinal inflammatory diseases (such as ulcerative colitis, Crohn's disease, etc.); Use oral antibiotics or probiotics within 3 months. 5. Patients who the researchers think are not suitable for participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Skin CT and skin pathology: thickness of stratum corneum and spinous layer, degree of inflammatory cell infiltration, distribution and density of melanocytes, etc.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Obesity: BMI, waist-to-hip ratio, %EWL, etc.; Type 2 diabetes: ADA diabetes relief criteria; other metabolic indicators: blood sugar, blood lipids, blood pressure, inflammatory factors, and intestinal hormones.; | — |
Countries
China
Contacts
Public ContactZhu Shaihong
Xiangya Third Hospital of Central South University
Outcome results
None listed