syndrome disease
Conditions
Interventions
experimental group:RTX treatment
Sponsors
Jiangsu Province People's Hospital
Eligibility
Sex/Gender
Male
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) 18-75 years old (including 18 and 75 years old), regardless of gender and nationality; (2) The patients with refractory membranous nephropathy (MN) or newly diagnosed membranous nephropathy were at medium or high risk. (3) The laboratory examination met the following conditions: 24h urinary protein >= 3.5g, serum albumin = 30 ml / min / 1.73 m2; CD19 + B lymphocyte count > 5 / mm3, neutrophil count >= 1.5 x 10^9 / L and platelet count >= 75 x 10^9 / L; (4) Informed consent was signed by the patient.
Exclusion criteria
Exclusion criteria: (1) eGFR < 30 ml/min/1.73 m2 (2) The onset of nephrotic syndrome in infants and children; (3) Abnormal liver function, alanine aminotransferase or aspartate aminotransferase 2 times higher than the upper limit of normal value; (4) Potential hepatitis B or HIV positive, systemic lupus erythematosus, amyloidosis, allergic purpura; (5) Secondary nephrotic syndrome (6) More than one infection (sepsis, sinusitis, bronchitis, pneumonia, febrile infection, herpes zoster, respiratory tract infection, fungal infection, infection of unknown etiology) occurred in the past month; (7) Current or previous anti tuberculosis treatment; (8) Severe impairment of immune response (such as hypoimmunoglobulinemia, severe decrease of CD4 or CD8 cell count) (9) Severe cardiovascular and cerebrovascular complications such as myocardial infarction, heart failure and cerebral hemorrhage occurred in the past six months; (10) Patients with neutrophil count less than 1.5 x 10^9 / L and / or platelet count less than 75 x 10^9 / l had CD19 + B lymphocyte count less than 5 / mm3; (11) Immunosuppressants (cytotoxic drugs, Tripterygium wilfordii preparations, etc.) can not be stopped temporarily; (12) Pregnancy or lactation; (13) Allergic to active ingredients or any excipients in the prescription.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| remission rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of complications; | — |
Countries
China
Contacts
Public ContactChangying Xing
Department of Nephrology, Jiangsu Province People's Hospital
Outcome results
None listed