Neutrophil gelatinase-associated lipid delivery protein (NGAL) and postoperative delirium in patients undergoing cardiopulmonary bypass

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2100042638

Enrollment

Unknown

Registered

2021-01-24

Start date

2021-02-01

Completion date

Unknown

Last updated

2021-05-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative delirium

Interventions

Gold Standard:Clinical outcome

Index test:Neutrophil&#32

gelatinase-associated&#32

lipid&#32

delivery&#32

protein&#32

(NGAL).

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: ASA class II or III, older than 18 years of age, body mass index of 18 to 25 kg/m2, 100 patients with heart valve replacement surgery under extracorporeal circulation.

Exclusion criteria

Exclusion criteria: Preoperative delirium or other severe cognitive impairment, preoperative systemic or local inflammatory response, blood routine examination suggested an increase in the percentage of leukocytes and/or neutrophils, moderate and severe liver and kidney function injury, and previous history of traumatic brain surgery within 3 months.

Design outcomes

Primary

Measure	Time frame
neutrophilgelatinase-associatedlipocalin;SEN, SPE, ACC, AUC of ROC;	—

Secondary

Measure	Time frame
IL-1;IL-6;S-100ß;	—

Countries

China

Contacts

Public ContactLi Ping

The First Affiliated Hospital of Chongqing Medical University

anesolee@hotmail.com+86 13062337738

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026