Thoracoscopic lung surgery
Conditions
Interventions
control group:Nil
esketamine group:After anesthesia induction, the patients received intravenous injection of 0.1mg/kg ketamine, and then continuous intraoperative intravenous infusion of 0.1mg/kg/h esketamine until th
Sponsors
The Second Affiliated Hospital of Nantong University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 65 years; 2. ASA I-III; 3. Lung tumor surgery under endotracheal intubation under general anesthesia is planned, including wedge resection, segmental resection, partial pulmonary resection, lobectomy, and unilateral radical resection of lung cancer; 4. Plan to stay in hospital >= 48 hours after surgery.
Exclusion criteria
Exclusion criteria: 1. A history of allergy to ketamine or contraindications to its use (severe risk of elevated blood pressure and intracranial pressure, poorly controlled or untreated hypertension, untreated or undertreated hyperthyroidism, gastrointestinal bleeding); 2. Have mental illness and other chronic pain or other conditions that may confuse the analgesic reaction; 3. Unable to read and write Chinese, communication barriers; 4. Emergency surgery or trauma patients; 5. Previous history of thoracotomy or intraoperative knowledge;Additional intercostal incisions were needed during the operation. 6. Admitted to ICU after surgery; 7. Refuse to attend.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Inflammatory factors and oxidative stress indicators; | — |
Secondary
| Measure | Time frame |
|---|---|
| Airway resistance after single lung ventilation;pulmonary compliance;The incidence of hypoxemia; | — |
Countries
China
Contacts
Public ContactBoxiang Du
The Second Affiliated Hospital of Nantong University
Outcome results
None listed