Pathogenesis of endolymphatic hydrops related diseases

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2100042580

Enrollment

Unknown

Registered

2021-01-23

Start date

2021-02-01

Completion date

Unknown

Last updated

2021-05-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ear diseases

Interventions

Endolymphatic hydrops group:None

Acoustic neuroma group:None

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Experimental group: 30cases (adult, aged > 18 years) 1) Gadolinium enhanced MRI of inner ear confirmed endolymphatic hydrops; 2) Preoperative pure tone audiometry showed severe sensorineural hearing loss (0.5,1,2 mean hearing threshold > 70dB); 3) Reach the operation standard and operate in our hospital; 4) Informed consent of patients. Control group: vestibular tissue specimens and endolymphatic sac tissue specimens of 30 patients (adult, age > 18 years old) with acoustic neuroma underwent labyrinthine surgery.

Exclusion criteria

Exclusion criteria: Combined with other space occupying lesions; combined with other diseases that will affect the results of this study and the health of patients.

Design outcomes

Primary

Measure	Time frame
RNA-seq in vestibular specimen;	—

Countries

China

Contacts

Public ContactDongdong Ren

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dongdong_ren@163.com+86 13801913332

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026