Infectious keratitis
Conditions
Interventions
Infectious keratitis group:Nil
Normal control group:Nil
Sponsors
The first affiliated Hospital of Northwestern University, Xi'an No.1 Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Fungal keratitis: obvious foreign body sensation or tingling, blurred vision and other symptoms in the eyes, accompanied by a small amount of secretions. Typical signs include hyphae quilt, pseudopodia, immune ring, endothelial plaque, satellite focus and anterior chamber empyema. The smear examination of diseased corneal tissue showed fungal keratitis. 2. Bacterial keratitis: symptoms such as sore or tingling eyes, photophobia, tears, sudden decline in vision, headache on the affected side, etc. Eye examination shows eyelid edema, spasm and mixed hyperemia; there are yellow-white infiltrating foci on the cornea, the boundary is blurred, the surrounding corneal tissue edema, the focus quickly forms ulcers, the bottom is dirty, and the surface is often covered with necrotic tissue; because the toxin infiltrates into the anterior chamber, it is often accompanied by iridocyclitis, fibrin-like exudation of the anterior chamber or empyema in the anterior chamber. The smear examination of diseased corneal tissue showed bacterial keratitis. 3. Herpes simplex keratitis: Primary infection: it often occurs in childhood and is usually complicated with upper respiratory tract infection. the main signs of the eyes are follicular conjunctivitis, punctate or dendritic keratitis, and skin herpes in the lip and trigeminal nerve distribution area of the head and face at the same time. Recurrent infection: often due to upper respiratory tract infection, menstruation or excessive fatigue and other inducements. The eyes show typical corneal damage, such as dendritic keratitis, map keratitis, stromal keratitis with corneal ulcer and other typical signs, which lead to corneal anaesthesia.
Exclusion criteria
Exclusion criteria: 1. Patients who have been given local or systemic antibiotics and hormones in the past month; 2. Patients currently undergoing treatment for infectious keratitis; 3. Patients with systemic diseases such as Sjogren's syndrome and diabetes that affect the ocular surface; 4. Patients with a history of eye trauma or surgery within one year; 5. Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Abundance and type of flora; | — |
Countries
China
Contacts
Public ContactCheng Yan
The First Affiliated Hospital of Northwestern University, Xi'an No.1 Hospital
Outcome results
None listed